Reactions of Thiamine Disulfide Monosulfoxides with Mercaptans

Studies of reactions between flavins and quinones, mercaptans, and enolates.

A. Equilibrium and second-order rate constants have been measured for the redox reaction between phthaloquinone and dihydroriboflavin (and its reverse) at a number of pH values. The equilibria and kinetic determinations are in agreement. No intermediates could be found in the reaction, and it is proposed that with this and other quinones electron transfer occurs within a complex of the flavin a...

Affinity of Thiamine Propyl Disulfide-s35 to Blood.

The fact that the tissue affinity of thiamine propyl disulfide (TPD) is superior to that of thiamin hydrochloride has been shown by many studies in this country as well as in foreign countries. Especially, the distribution of thiamine in the blood after administration of TPD is worthy of note, i.e., the thiamine concentra tion in the blood, particularly in blood cells, is markedly higher after ...

Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study.

OBJECTIVES In a Pilot Study, the clinical and biochemical effects of thiamine tetrahydrofurfuryl disulfide (TTFD) on autistic spectrum children were investigated. SUBJECTS AND METHODS Ten children were studied. Diagnosis was confirmed through the use of form E2, a computer assessed symptom score. For practical reasons, TTFD was administered twice daily for two months in the form of rectal sup...

REACTIONS OF DIHYDROPYRIDINES WITH BENZYNE

Reactions of 1 ,Zdihydropyridines (la-c) and 1,4-dihydropyridines (2a-c) in the presence of benzyne (3) under thermal conditions, and in the case of (2c) under photochemical conditions, have been investigated. Benzyne acts as an oxidizing agent to convert dihydropyridine (la) and (2a) to the corresponding pyridine (4) or adds as a dienophile to (lb-c).

PROBING THE ACTIVE SITE OF RHODANESE WITH DISULFIDE REAGENTS